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Med.36378040010770114164180
Praxi.3837804001074571112152171187
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PŘEHLEDOVÉ4549200012660124182256312369444520587645
ČLÁNKY5216200012660115187259327395
Kolorektální153936001063372104143179211247281317348390407
karcinom196236001063375111145163204245299
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ordinaci232836001063975114132173213246264
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Kolorektální34089002981472793454825726988289201047111112501315
karcinom170389002981302573474545196587951001
v27528900298127
ordinaci29288900298138228370435575700807872
praktického38488900298144234358486579645752881100411451282
lékaře3401150029866192322448538664
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jak12211150029870196324
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osoby301211500298138241378520641
ve370111500298128249
zvýšeném3998115002981132423734756007418661073
riziku3401410029891154266333462600
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kdy116414100298130269394
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MUDr.3401810013793168245287311
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Ph.D.1,13641810013764127156235261161818200803651
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prof.17701810013766108172209236
MUDr.20281810013793168245287310
Jan23601810013746104168
Bureš,25511810013766130172231279309
CSc.1,28821810013765125175205308018200803651
2,314418200803631811810013729
Mgr.32321810013793158200223
Ondřej34771810013779144210253311343
Ngo,38421810013776141204232
Ph.D.3,40961810013764128157235261436018200803653
4,442618200803644631810013729
Ing.340196001373196161190
Monika5521960013793157222252311370
Ambrožová3,9441960013772167233275339390454511569151219700803653
4,157819700803616151960013729
Mgr.16661960013793158200223
Renata19111960013766124189247287346
Chloupková3,22791960013766129160224288354414477533591286919700803653
4,293519700803629731960013729
RNDr.30241960013765142219261285
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Májek,36951960013793152183242302334
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prof.3402110013766108172210236
MUDr.5982110013793168245287310
Miroslav9312110013793124166229277308366423
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Ph.D.1,17982110013764127156235261205221200803651
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doc.22042110013765129179209
MUDr.24352110013793168245288311
Štěpán2768211001375998157223281346
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Ph.D.1,36702110013763127156234260392421200803651
23988212008036
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klinika,692226001335178103163188239293315
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lékařská1128226001332681132186221265316369
fakulta1521226001333285136197222258311
UK18552260013371131
a20092260013353
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VFN23922260013362116186
Praha2601226001335993146206259
2Ústav3402420078333732410013371113150203254
gastrointestinální6502410013361114156193228288313374409462505542567627680705765790
onkologie,14632410013361122173231257317379404459481
ÚVN19672410013371133205
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VFN22742410013361115185
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screeningové765256001334493128183238299324384446506557611
centrum,13992560013349103164199234294386408
Ústav18302560013372113150203254
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informací2820256001332686118178214305358407431
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4Institut340272007833374271001332687129166191227287323
biostatistiky720271001336388148191228281316341384421446496551
a12952710013353
analýz,13712710013353113166191243292316
LF17102710013352104
MU,18382710013388159178
Brno2039271001336096157217
Kolorektální3403220012155110134190224275323360409433489513
karcinom882322001214898131176200256312397
patří13083220012158107141174198
celosvětově1535322001214595120176216266316350405453503
k20673220012147
nejčastějším21363220012156108132178227267302352376416440525
malignitám26903220012184133157181238294318351401486
a32053220012149
zaujímá3276322001214394149174197282331
třetí3636322001213467117152175
místo3403360012183107146180234
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Praktičtí2648336001215385133180216239284319342
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mají32613360012183131155178
klíčovou346233600121477295139193240294349
roli340350001213286110132
nejen4893500012155105128178233
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oblasti8073500012155111135182220254276
primární1100350001215789112194241273328351
prevence1468350001215789138185233288332381
tohoto1866350001213386141195228281
onemocnění,21643500012155109159242296341395445500522543
ale2724350001214870120
také2861350001213381127175
v30543500012147
procesu3122350001215689142187235274328
časného3467350001214592131185235290344
zachycení340364001214392136191236279327382405
již76336400121244789
přítomných869364001215789112145198281336381424479
nádorových13653640012155103159213246300347397440494
lézí.1877364001212373116139159
V20543640012155
úvodní21303640012155102156212267290
části2437364001214593132165188
přehledu2642364001215789138193217266323377
je3037364001212474
podrobně31283640012157112168201255311366416
diskutována3562364001215678117163218340378001213285130177231277
epidemiologie6343780012149104127181230312334387410463518540589
kolorektálního1239378001214698121175207255300335382405458480536589
karcinomu,1844378001214694125168190243297378431451
současná2311378001213993146190237275328374
data27023780012155101133180
o28983780012154
incidenci2972378001212376120142196245299343365
a33533780012147
mortalitě,34203780012182135167201249271293325372391
význam340392001214899144199247331
a6953920012148
výsledky764392001214899139162212270316367
populačního11553920012157113170225249297341397420477532
screeningového1711392001214085117167218274297352408463511560616671
programu2406392001215790144201234282365420
v28503920012148
České29203920012158106146193242
republice.3186392001213382139195252276299343392413
Dále36233920012166114138188
je340406001212475
zdůrazněna4414060012143100154187235279334384440488
role956406001213287111161
primární1144406001215790114197245277333356
péče15274060012157108154203
v17564060012148
podpoře18264060012157112170226282315365
screeningových2218406001213984117166217273296351408463510560604659
programů2904406001215790145201234282365420
a33514060012148
v34204060012148
časném3490406001214493132187238321
zachycení340420001214392137192237281330385408
asymptomatických766420001214887135219276308362446494526549593640690734788
jedinců1572420001212575132155210255309
s18994200012139
vysokým1960420001214898137192240290374
rizikem235142000121335699122169218301
vzniku2670420001214892148171217272
kolorektálního29604200012147101125179212262309345393417472495552607
karcinomu.35844200012147961281731953404340012155111194249270
Druhá6314340012166100155210258
část910434001214594133167
článku1098434001214467115171217273
se1392434001213990
již150343400121244790
specificky1614434001213996147193216245271316362413
zaměřuje2048434001214292175226257313337387
na24564340012155103
problematiku2580434001215790145202226276360408440463510565
klinického316643400121477295150173218265314369424
hodnocení361143400121561111683404480012155109154202256279
osob636448001215492146202
v8554480012148
primární923448001215688111193240272327349
péči,12894480012156106151173193
zejména1499448001214291115196246301348
s18644480012139
ohledem19234480012154109132181237287369
na23094480012155102
identifikaci2428448001212378128182214236265290336384428450
a28954480012148
stratifikaci2963448001213972104152183206234260306354398420
rizikových340044800121325597120166218264314357411
jedinců340462001212474131154208253307
s6654620012139
pozitivní7254620012157112153177209232280336358
rodinnou1101462001213287143166221276330385
anamnézou15044620012148102150233287337380434489
kolorektálního20114620012146100124178211260307343391414469491548603
karcinomu.2631462001214796128172194249304387441462
Diskutovány3110462001216790129175230263316363411466511
jsou3638462001212563118173
doporučené3404760012156112169225257313358407462513
strategie874476001213973106154187236293316366
sledování1261476001213963113170225273321376399
těchto1681476001213382128183215269
pacientů19714760012157106150173224279312366
a23584760012148
optimální24284760012155112145168251299322378401
postupy28494760012157113152186241298344
pro3214476001215790144
jejich337947600121247599122167222
další36214760012157105128167190
vyšetřování340490001214899138189222254309356404460483
a8444900012148
případnou914490001215689113169218275330385441
referenci1376490001213282112162195245301346369
ke1766490001214796
specialistům.1883490001213996147193216263287310349383438521542
Klíčová340507001246190118163221273326
slova:689507001244372130182235261
kolorektální9735070012147101125180213263310346395418473496
karcinom,1493507001214796129173196251306390411
screening,1928507001213985117167218273296352408428
primární2380507001215790114197245278333356
péče,27605070012157108154203223
rodinná3007507001213387144168223278326
anamnéza,33575070012148103151235290340384433454
hereditární3405210012155106139189246269302351383439462
syndromy.824521001213987144200233287371417433
Colorectal3405490012459116145203242295341380434462
cancer822549001244599158203256295
in1138549001242786
general12445490012459112172225264317345
practice1609549001246099151197236264310363
–19925490012450
how20625490012459117192
to2275549001243695
identify2390549001242787141200237266301356
individuals2766549001242887147175229257317376429457501
at340563001245390
increased450563001242786132171224278322375436
risk906563001243866110165
and10915630012453112172
when12835630012476135189248
to1552563001243695
screen1667563001244389128181235295
first1982563001243463102146183
degree21855630012460113173212265319
relatives2524563001243892120174211239293345389
Colorectal3405800012158112136191224273319354403427
cancer795580001214493148193242275
belongs10985800012157108132187243299338
among14645800012148131186242298
the1790580001213388138
most19565800012184139178212
common2196580001214598182265320376
malignancies26005800012183131155178233289337392437460510550
worldwide31775800012174128161185242315339396446
and36515800012148103160
ranks340594001213382138186229
the598594001213389140
third767594001213389113146203
place998594001215882131177226
in1253594001212480
the1361594001213490141
incidence1531594001212379125148206257313359409
among19685940012149133189246303
all229959400121497397
malignant24245940012185133157181237294342398431
tumors.2884594001213389173229263304326
General32385940012166118174225259308332
practitioners359959400121579114018534060800121345791115171227279312353
play722608001215883132178
a9296080012149
crucial1000608001214578135181204253277
role1306608001213389114165
not15006080012156112146
only16756080012155112136184
in1889608001212379
the1997608001213490142
primary2168608001215791115199248282333
prevention2530608001215891142190241297330354410467
of3026608001215585
this3140608001213490113153
disease3322608001215881121173222261313
but36646080012158114148
also340622001214872111166
in529622001212479
the631622001213388139
early793622001215098131154202
detection10186220012157107140190235271294349404
of1446622001215584
existing1553622001215097121160194217272328
neoplastic19056220012155106161219243291330364387431
lesions.2360622001212374113136191247286307
The26906220012150106157
first287062200121295688128162
part30566220012156105138174
of3253622001215584
this3360622001213388112151
review3534622001213382130154204277
discusses340636001215680119164219258297347387
in750636001212479
detail8526360012156107140189212235
the1111636001213388138
epidemiology12736360012150107131187237321344399423478535583
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colorectal1987636001214498122177210260306341390413
cancer,2424636001214493148193242275291
current2739636001214499132165215270303
data30656360012156104137186
on32746360012155111
incidence3408636001212378123146203253309354403
and3406500012148103160
mortality,5186500012183138171207255279302335384400
and9366500012148103160
the1114650001213388138
importance12706500012123106163219251287336391436485
and17736500012148103160
outcomes19506500012155110143187241324374414
of2382650001215584
the2483650001213489139
population-based26406500012157112169225248296328351406462494552600639690747
screening3405650001213984116166217273296351407
program340664001215790144201234282365
in726664001212378
the824664001213389139
Czech9836640012158103153199254
Republic.12576640012154104161217273297320365387
Furthermore,16646640012149101134170225275308392447480530550
the2234664001213388139
role2393664001213387111162
of2575664001215584
primary2679664001215790113196245277327
care3027664001214493126175
is3223664001212362
emphasized33056640012150134191247295334357399449507
in340678001212379
promoting437678001215790144228283316339394450
screening905678001214085118167218274297352409
participation13326780012157105138174197242265321370402425480536
and18866780012149104161
in2065678001212378
the2162678001213388138
early2319678001215098130154202
identification2539678001212380130186218241271297341390423446501556
of3114678001215584
asymptomatic3216678001214887136220276310364447495528551596
individuals340692001212379135158207231287342390413452
at811692001214881
high911692001215578134189
risk111969200121335796142
of1280692001215584
colorectal1383692001214599123178211260306341390414
cancer.1816692001214493148193242275292
The21266920012150106157
second2302692001213990136189245302
part26226920012157106139174
of2815692001215584
the2918692001213388139
article3076692001214880116139184207258
specifically3352692001214096148193216246272316365389412459
addresses3407060012148105161193243282321372411
the769706001213388138
clinical92570600121446790145168213261285
assessment1228706001214887126176215254337387443475
of1721706001215484
subjects1822706001214094151174224270305345
in2185706001212479
primary2281706001215790113196244276327
care,2625706001214594126176195
particularly28387060012157105138174196241296319367399423470
focusing3326706001212984129184223246301356
on37007060012155111
the340720001213388139
identification497720001212380130186218241271297341390423446501556
and10727200012148103160
risk125072000121335695142
stratification1410720001214074106155187210240266311359392415470526
of1954720001215584
individuals2056720001212379135158207230287342390413452
with2526720001217498131186
a27307200012148
positive28007200012157113152175208231279328
family3147720001212978161184207255
history3420720001215579118152206239289
of3727720001215584
colorectal340734001214599123178211261307342391414
cancer.783734001214493149194243276292
Recommended11037340012154105151204288371422478534585642
surveillance1773734001214095127178228251274298346401446495
strategies2296734001214074107155188237294317367407
for2731734001212985118
these2877734001213388139178229
patients31347340012157106138161212267300341
are3503734001214881130
discussed,3662734001215679119340748001214499137176226282303
as660748001214887
well7647480012173122146168
as950748001214886
optimal10547480012154111143166248296319
approaches13907480012148104160193247295339393443482
for1890748001212983115
further2023748001212984116152206256288
evaluation2329748001214996144167221269301323378433
and27797480012148103159
referral2955748001213382111161193226274297
to3269748001213386
specialists.3373748001213995145190213260283306344378418439
Key3407650012460108156
words:5087650012474128163220260283
colorectal803765001214494115167196243285317362383
cancer,1198765001214489141182228257270
screening,1481765001213980110156203255275327379397
primary1891765001215585106185229258305
care,2209765001214389118164181
family2403765001212874153173193237
history,2652765001215575111141192221268281
hereditary29467650012154101131177231251281326355402
syndromes.3360765001213984136189219270349396432451
DECLARATIONS:4068309008648871301662142563043393604124625014570309008514
Declaration406832300874987120141179207245272292334376
of445832300874166
originality:45383230087406888131151193231252272299338358
The406833400853473109
manuscript418833400855791130168195227249266306329
is452833400851644
original45833340085386178117133172205222
and481633400853472112
has49393340085387299
not50503340085387699
been516133400853975110149
published532133400854078118135151178217252292
or406834500853862
submitted414534500852867108167184208234269310
elsewhere.44703450085355381117169209246269305320
Ethical406835900873764107127160198219
principles43013590087427090132165185229249288319
compliance:463535900873172134177198218256298331369388
The406837000853678116
authors420537000853475100142183208238
attest44643700085356087124154179
that466437000852465101126
their481137000852465103121146
study49783700085295596138173
was517337000855389118
approved531337000853477119144185220257300
by406838100854073
the41583810085236399
local42743810085165689124141
Ethical44323810085345898115147182199
Committee464838100854179139198215239265300337
and500138100853474114
is513238100851745
in519438100851656
compliance526638100853270130170188205239279311347
with40683920085537298140
human423639200854081143180221
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