Med. Pro Praxi 2008; 5(3): 113-116 [Prakt. lékáren. 2006; 2(3): 118-122]

Xenobiotika jako alternativa hormonální substituce u žen v klimakteriu

MUDr. Marie Vrzáňová1, MUDr. Jana Heresová CSc2,3
1 Interní klinika fakultní nemocnice Motol a 2. lékařské fakulty Univerzity Karlovy v Praze
2 Endokrinologický ústav, Praha
3 Klinika nukleární medicíny UK 2. LF Praha a FN Motol

Fytoestrogeny (FE) jsou přirozené aktivní látky obsažené v rostlinách, u vyšších živočichů a u člověka jsou charakterizovány afinitou k estrogennímu receptoru (ER). Chemickou strukturou jsou fytoestrogeny vzdálené estrogenům, společným rysem je fenolové jádro v molekule, které umožňuje vazbu na ER s následnou metabolickou aktivitou a vylučováním podobně jako endogenní estrogeny. Nejznámější skupinou fytoestrogenů jsou izoflavony, kumestany, flavony, lignany a další, liší se svými estrogenními vlastnostmi. Rizika HST u žen v klimakteriu jsou prokazatelná, FE vytváří možnosti alternativní léčby u žen, které estrogeny nemohou užívat.

Keywords: fytoestrogeny, izoflavony, estrogeny, menopauza

Published: May 21, 2008  Show citation

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Vrzáňová M, Heresová J. Xenobiotika jako alternativa hormonální substituce u žen v klimakteriu. Med. praxi. 2008;5(3):113-116.
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    References

    1. Barnes S. The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Res Treat 1997; 46(2-3): 169-179. Go to original source... Go to PubMed...
    2. Donát J. Kdy volit fytoestrogeny z červeného jetele? Klimakterická medicina 2005; 4(10): 15-16.
    3. Grady D, et al. Cardiovascular disease outcomes during 6-8 years of hormone therapy. JAMA 2002; 288(7): 49-57. Go to original source... Go to PubMed...
    4. Herrington DM, Reboussin DM,Klein KP, et al. The estrogen replacement and aterosclerosis (ERA) study - study design and baseline characteristics of the cohort. Control Clin Trials 2000; 21(3): 257-285. Go to original source... Go to PubMed...
    5. Hulley S, Grady D, Bush T, et al. Heart and estrogen/progestin replacement study (HERS) research group. JAMA 1998; 280(7): 605-613. Go to original source... Go to PubMed...
    6. Chi-Ling Chen, Weis NS, Newcomb P, Barlow W. White E. Hormone replacement therapy in relation to breast cancer JAMA 2002; 287(6): 734-737. Go to original source... Go to PubMed...
    7. Liggins J, Bluck IJ, Runswick S, Atkinson C, Coward WA, Bingham SA. Daidzein and genistein contents of vegetables. Br J Nutr 2000; 84(5): 717-725. Go to original source... Go to PubMed...
    8. Newton KM, Reed S, Grothaus L, et al. The herbal alternatives for menopause (HALT) study: beckground and study design. Maturitas 2005; 52: 134-146. Go to original source... Go to PubMed...
    9. Nagata C, Takatsuka N, Kawakami N, Shimizu H. Soy product intake and premenopausal hysterectomy in follow-up study of Japanes women. Eur J Clin Nutr 2001; 55(9): 773-777. Go to original source... Go to PubMed...
    10. Strnad P. Závěrečná zpráva půlroční studie pro firmu Biovit impex Co. s přípravkem Swis Herbal Remedies Ltd., Kanada-SwisEstrovone 75 mg, 2001; Gynekologicko-porodnická klinika FN Motol, Praha.
    11. Stárka L, a kolektiv. Aktuální endokrinologie, Maxdorf, 1999; 738: (Fytoestrogeny 189-98).
    12. Šormová I. Fytoestrogeny v léčbě klimakterického syndromu. Klimakterická medicina 2003; 1(8): 6-8.
    13. Wang C, Kurzer MS. Efekt of phytoestrogens on DNA synthesi in MCF-7 cells in the presence of estradiol or growth factors. Nutr Cancer 1998; 31 (2): 90-100. Go to original source... Go to PubMed...
    14. Writing group for the Women´s health initiative investigators. Risk and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 2002; 288(7): 321-333.
    15. Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol. Biomarkers Prev 1998; 7(12): 1101-1108. Go to PubMed...

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