Med. praxi. 2012;9(4):174-178

Vitamin D and risk of cardiovascular diseases and diabetes

prof.MUDr.Ondřej Topolčan, CSc.1, doc.RNDr.Judita Kinkorová, CSc.2, prof.MUDr.Karel Vondra, DrSc.3
1 Fakultní nemocnice Plzeň
2 Technologické centrum AV ČR Praha
3 Endokrinologický ústav Praha

Vitamin D is a hormone in the genesis of applying a wide range of diseases. The aim of the article was to show the role of D deficiency in

cardiovascular disease and diabetes. For both these groups of diseases is the lack of vitamin D a significant risk factor for development and

disease. However, no long-term prospective studies that have shown vitamin D supplementation as this adversely affect the state.

Keywords: D vitamine, cardiovascular diseases, 2 diabetes types

Published: April 25, 2012  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Topolčan O, Kinkorová J, Vondra K. Vitamin D and risk of cardiovascular diseases and diabetes. Med. praxi. 2012;9(4):174-178.
Download citation

References

  1. Holick MF. McCollum Award Lecture, 1994: vitamin D - new horizons for the 21st century. Am J Clin Nutr 1994; 60: 619-630. Go to original source... Go to PubMed...
  2. Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 1988; 67: 373-378. Go to original source... Go to PubMed...
  3. Hewison M, Zehnder D, Chakraverty R, Adams JS. Vitamin D and barrier function: a novel role for extra-renal 1 alphahydroxylase. Mol Cell Endocrinol 2004; 215: 31-38. Go to original source... Go to PubMed...
  4. Bikle DD, Gee E, Halloran B, et al. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest 1984; 74: 1966-1971. Go to original source... Go to PubMed...
  5. Haussler MR, Jurutka PW, Mizwicki M, et al. Vitamin D receptor (VDR) -mediated actions of 1?, 25(OH) 2vitamin D3: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab 2011; 25: 543-559. Go to original source... Go to PubMed...
  6. Sugden JA, Davies JI, Witham, et al. Vitamin D improves endothelial function in patients with type 2 diabetes and low vitamin D levels. Diabet Med 2008; 25: 320-325. Go to original source... Go to PubMed...
  7. Forman JP, Williams JS, Fisher ND. Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans. Hypertension. 2010; 55(5): 1283 Go to original source... Go to PubMed...
  8. Tishkoff DX, Nibbelink Ka, Holmberg KH, et al. Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility. Endocrinology 2008; 149: 558-564. Go to original source... Go to PubMed...
  9. Aoshima Y, Mizobuchi M, Ogata H, Kumata C, Nakazawa A, Kondo F, Ono N, Koiwa F, Kinugasa E, Akizawa T. Vitamin D receptor activators inhibit vascular smooth muscle cell mineralization induced by phosphate and TNF-?. Nephrol Dial Transplant. 2012 Jan 28. Go to original source... Go to PubMed...
  10. Kota SK, Kota SK, Jammula S, Meher LK, Panda S, Tripathy PR, Modi KD. Renin-angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study. Indian J Endocrinol Metab. 2011; 15 Suppl. Go to original source... Go to PubMed...
  11. Hsia J, Heiss G, Ren H, et al. Women's Health Initiative Investigators. Calcium/vitamin D supplementation and cardiovascular events. Circulation. 2007; 115: 846-854. Go to original source... Go to PubMed...
  12. Giovannucci E. Vitamin D and cardiovascular disease. Curr Atheroscler Rep. 2009; 11(6): 456-461. Review. Go to original source... Go to PubMed...
  13. Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008; 117: 503-511. Go to original source... Go to PubMed...
  14. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008; 168: 1174-1180. Go to original source... Go to PubMed...
  15. Dobnig H, Pilz S, Scharnagl H, Renner W, et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008; 168: 1340. Go to original source... Go to PubMed...
  16. Pittas AG, Chung M, Trikalinos T, et al. Systematic review. Vitamin D and cardiometabolic outcomes. Ann Intern Med 2010; 152: 307-310. Go to original source... Go to PubMed...
  17. Kendrick J, Targher G, Smits G, Chonchol M. 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis. 2009; 205(1): 255-260. Go to original source... Go to PubMed...
  18. Wolf M. Should activated vitamin D be used in patients with end-stage renal disease and low levels of parathyroid hormone? Semin Dial. 2011; 24(4): 428-434. Go to original source... Go to PubMed...
  19. Patel R, Rizvi A, A. Vitamin D deficiency in patients with congestive heart failure: mechanisms, manifestations, and management. South Med J. 2011; 104(5): 325-330. Go to original source... Go to PubMed...
  20. Forouhi NG, Luan J, Cooper A, et al. Baseline 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistence Diabetes 2008; 57: 2619-2626. Go to original source... Go to PubMed...
  21. Pittas AG, Lau J, Hu FB, et al. The role of vitamin D and calcium in type 2 diabetes.A systematic review and metaanalysis. J Clin Endocrinol Metab. 2007; 92(6): 2017-2029. Review. Go to original source... Go to PubMed...
  22. Parker J, Hashmi O, Dutton D, et al. Levels of vitamin D and cardiometabolic disorders. Systematic review and meta-analysis Review Maturitas. 2010; 5(3): 225-236. Go to original source... Go to PubMed...
  23. Lau SL, Gunton JE, Athayde NP, et al. Serum 25-hydroxyvitamin and glycated hemoglobin levels in women with gestational diabetes mellitus Med J Aust 2011; 194(7): 334-337. Go to original source... Go to PubMed...
  24. Pittas AG, Hartus SS, Stark PC, et al. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care 2007; 30: 980-986. Go to original source... Go to PubMed...




Medicine for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.