Med. praxi 2012; 9(8-9): 342-346

Schizophrenia: diagnostics and current therapeutic options

doc.MUDr.Pavel Mohr, Ph.D.

Psychiatrické centrum Praha

3. lékařská fakulta UK, Praha

Psychotic disorders are characterized by a loss of touch with reality. The most important disorder from the group is schizophrenia,

illness resulting in severe functional impairment. Diagnosis is based primarily on clinical symptomatology and exclusion of other

etiology, either organic or toxic. Treatment of schizophrenia is complex, combining pharmacotherapy and psychosocial interventions.

Antipsychotics represent the causal therapy. Currently, the most frequently prescribed drugs are so called atypical antipsychotics. The

profile of side effects depends on the antipsychotic receptor affinity. Metabolic side effects and weight gain are gaining more attention,

replacing traditional movement disorders (EPS) and hyperprolactinemia. Thus, it is of utmost importance to monitor closely physical

condition of patients treated with antipsychotics. The treatment is long-term, not only restricted to acute phase; maintenance therapy

for relapse prevention is essential. In case of low adherence with drug treatment, long-term acting injection formulas of antipsychotic

can be administered.

Keywords: psychosis, schizophrenia, diagnostics, therapy, antipsychotics

Published: September 25, 2012  Show citation