Fixed combination: a new trend in hypertension management

Due to its prevalence of 20–50 % in the adult population in industrialized countries, hypertension along with diabetes, obesity, hyperlipidaemia,

and smoking is among the major risk factors for cardiovascular mortality. This risk is significantly reduced by achieving target

blood pressure levels with adequate treatment and lifestyle measures. The low proportion of hypertensive patients who achieve these

target levels remains a problem. In the majority of them, it cannot be achieved by using monotherapy, and combination therapy is the

method of choice. Fixed drug combinations are more comfortable for the patient, improve their relationship to long-term treatment,

and are more effective and prognostically more suitable; therefore, they should be considered and preferred in the management of hypertension.

Being acquainted with currently available fixed double combinations and selecting an ideal one to treat a particular patient

with respect to comorbidities has become a new must in the modern management of hypertension.

Keywords: hypertension, combination therapy, fixed combination