Med. praxi. 2014;11(1):22-25
The use of strong opioids in chronic pain treatment
- Centrum pro léčbu bolesti a paliativní medicínu, s. r. o., Zlín
The effective management of chronic pain is fundamental goal for all clinicians, who treat the pain. Nociceptive and neuropathic pain
are two basic kinds of pain, which appears separetly or in combination. The three-step analgesic ladder developed by the World Health
Organisation (WHO) outlines these opioids in the management of cancer pain, and these widely accepted and extensively validated
guidelines have also been influential in the application of opioid therapy for treatment of chronic, non-malignant pain.
Potent opioids – such as morfin and the newer-generation agents (fentanyl, buprenorfin, oxycodon, hydromorfon and tapentadol) play
an important role in management of pain in patients with chronic pain. New opioid tapentadol is the first compound of the new pharmacological
class MOR-NRI, that combines μ-opioid-agonist and noradrenalin re-uptake inhibitor activities in one molecule.
Keywords: gabapentinoids drugs, opioids drugs, oxycodon, naloxon, tapentadol
Published: February 1, 2014 Show citation
References
- Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P, Jensen TS, Nurmko T. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision.Eur J Neurol 2010; 17: 1113-1123.
Go to original source... 
Go to PubMed... - Eissenberg E, Mc Nicol ED, Car DB. Efficacy of mi-opioi agonist in treatment of evoked neuropathic pain: systematic review of randomized controlled trials. Eur J Pain 2006; 10: 667-676. Go to original source... Go to PubMed...
- Kršiak M. Dávkování paracetamolu u dospělých s ohledem na hmotnost a kinetiku: simulace na počítači. Bolest 2011; 14(1): 23-28.
- Kršiak M. Novinky ve farmakologii opioidů s významem pro praxi. Paliat med lecba bolesti 2010; 3(1): 28-30.
- Riviiere PJ. Peripheral kappa-opioid agonists for visceral pain. Br J Pharmacol 2004; 141: 1331-1334. Go to original source... Go to PubMed...
- Staal C, Dimcevski AM, Anderson SD, et al. A comparative study of oxycodone and morfine in multimodal tissue differented experimental pain model. Pain 2006; 123: 28-36. Go to original source... Go to PubMed...
- Rokyta R, Kršiak M, Kozák J. Bolest Tigis, Praha 2012 přepracované doplněné vydání Bolest 2012; 24: 250.
- Rowbotham MC, Twilling L, Davies PS, et al. Oral opioid therapy for chronic peripheral and central neuropathic pain. N Engl J Med 2003; 348(13): 1223-1232. Go to original source... Go to PubMed...