Med. praxi. 2015;12(5):215-217
Post-thrombotic syndrome: risk of development, prevention, and treatment
- I. interní klinika kardiologická, FN a LF Olomouc
Post-thrombotic syndrome (PTS) is the most serious chronic complication of deep vein thrombosis (DVT). It is manifested by pain, swelling,
skin changes, and ulcerations in the affected limb. The pathophysiology involves post-thrombotic venous stenoses and valve destruction,
resulting in ambulatory venous hypertension. Recurrence of DVT increases the relative risk of PTS by about eight-fold, and there is also
an inverse relationship when the patients with PTS have a higher risk of DVT recurrence. Therefore, PTS prevention consists in preventing
the development, progression, and, in particular, recurrence of DVT. Currently, the treatment is mainly conservative. Correct and
timely diagnosis is of importance. The fact that PTS is not taken into consideration is one of the major problems concerning the disease.
Keywords: post-thrombotic syndrome, deep vein thrombosis, risk factors, prevention
Published: December 1, 2015 Show citation
References
- Eklof B, Perrin M, Konstantinos TD, Rutherford RB, Gloviczki P. Updated terminology of chronic venous disorders: The VEIN-TERM transatlantic interdisciplinary consensus document. J Vasc Surg 2009; 49: 498-501.
Go to original source... 
Go to PubMed... - Eklof B, Rutherford RB, Bergan JJ, et al. Revision of the CEAP classification of chronic venous disorders. Consensus statement. J Vasc Surg 2004; 40: 1248-1252. Go to original source... Go to PubMed...
- Broulíková A. Posttrombotický syndrom - pozdní komplikace žilní trombózy, patofyziologie, klinika, epidemiologie, prevence. Angiologie 2013: 52-55.
- Van Dongen CJ, Prandoni P, Frulla M, Marchiori A, Prins MH, Hutten BA. Relation between quality of anticoagulant treatment and the development of the postthrombotic syndrome. J Thromb Haemost. 2005; 3: 939-942. Go to original source...
- Ziegler S, Schillinger M, Maca TH, Minar E. Post-thrombotic syndrome after primary event of deep venous thrombosis 10 to 20 years ago. Thromb Res. 2001; 101: 23-33. Go to original source...
- Kahn SR, Ginsberg JS. The post-thrombotic syndrome: current knowledge, controversies, and directions for future research. Blood Rev. 2002; 16: 155-165. Go to original source... Go to PubMed...
- Jeanneret C, Aschwanden M, Staub D. Compression to prevent the postthrombotic syndrome. Phlebology 2014; 29: 71-77. Go to original source...
- Stain M, Schönauer V, Minar E, Bialonczyk C, Hirschl M, Weltermann A, Kyrle PA, Eichinger S. The post-thrombotic syndrome: risk factors and impact on the course of thrombotic disease. J Thromb Haemost. 2005; 3: 2671-2676. Go to original source... Go to PubMed...
- Tick LW, Kramer MH, Rosendaal FR, Faber WR, Doggen CJ. Risk factors for post-thrombotic syndrome in patients with a first deep venous thrombosis. J Thromb Haemost. 2008; 6: 2075-2081. Go to original source...
- López-Azkarreta I, Reus S, Marco P, Sánchez-Payá J, Murcia J, Manso M, Pérez-Mateo M. Prospective study of the risk factors for the development of post-thrombotic syndrome after proximal deep venous thrombosis. Med Clin (Barc). 2005; 125: 1-4. Go to original source...
- Meissner MH, Gloviczki P, Comerota AJ, et al. Early thrombus removal strategies for acute deep venous thrombosis: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2012; 55: 1449-1462. Go to original source...
- Kachroo S, Dylan B, Bookhart BK, et al. Quality of Life and Economic Costs Associated With Postthrombotic Syndrome. Am J Health Syst Pharm. 2012; 69: 567-572. Go to original source... Go to PubMed...
- Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, et al. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011; 53(Suppl. 5): 2S-48S. Go to original source...
- Coccheri S, Scondotto G, Agnelli G, et al. Randomised, double blind, multicentre, placebo controlled study of sulodexide in the treatment of venous leg ulcers. Thromb Haemost 2002; 87: 947-952. Go to original source... Go to PubMed...
- Du GC, Zhang MC, Zhao JC. Catheter-directed thrombolysis plus anticoagulation versus anticoagulation alone in the treatment of proximal deep vein thrombosis - a meta-analysis. Vasa. 2015; 44: 195-202. Go to original source...
- Casey ET, Murad MH, Zumaeta-Garcia M, et al. Treatment of acute iliofemoral deep vein thrombosis. J Vasc Surg. 2012; 55: 1463-1473. Go to original source...
- Guyatt GH, Akl EA, Crowther M, et al. Antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice quidelines. Chest 2012; 141(Suppl. 2): 7S-47S. Go to original source...