Med. praxi. 2016;13(3):131-135 [Dermatol. praxi. 2016;10(1):6-9]

Chronic sapontaneous urticaria - actual view on problematic disease

MUDr.Iva Karlová

Klinika chorob kožních a pohlavních LF UP a FN Olomouc

Urticaria is a skin condition characterised by wheals or angioedema. Wheals develop quickly in minutes, generally taking 3–8

hours, disappear up to 24 hours, angioedema could last up to 72 hours. Wheals may continue to appear for days, weeks or months.

In chronic urticaria symptoms persist for over 6 weeks. Chronic urticaria is divided into chronic inducibile urticaria and chronic

spontaneous urticaria. Chronic spontaneus urticaria is usually caused by infection, pseudoallergy, autoreactivity or an unknown

cause. The activity of urticaria is measured by urticaria activity score (UAS). Non sedating antihistamines is currently the first

choise medication for symptomatic treatment. After inssufficient effect of this therapy, the standard dosage of H-1 antihistamines

increases up to fourfold. If symptoms of urticaria persist despite this therapy, biological tratment with omalizumab is indicated.

Keywords: chronic spontaneuous urticaria, non sedating antihistaminics, omalizumab

Published: July 1, 2016  Show citation