Med. praxi. 2025;22(1):54-58 | DOI: 10.36290/med.2025.012

Uncompensated 64-year­‑old hypertensive patient with acute MI

MUDr. Milan Plíva

Kardiologické centrum Agel, Pardubice

Kardiologické oddělení, Interní klinika, Nemocnice Pardubice

The Czech Republic is one of the countries with a high prevalence of cardiovascular diseases. Arterial hypertension is the most important risk factor. Hypertension pre­valence in the Czech Republic is approximately 40% of the adult population. However, target blood pressure values or reduction of overall cardiovascular risk are still not achieved by the majority of those treated. The current guidelines for managing high blood pressure and arterial hypertension now recommend a target blood pressure of 120 - 129 mmHg systolic blood pressure within three months of starting treatment for most hypertensive patients. Fixed combinations of antihypertensive drugs remain the gold standard of treatment. It is their much wider use in everyday practice that may be the route to achieving target blood pressure values in most hypertensives. The first choice for most patients should be a fixed two-dose combination of a low-dose RAAS (renin-angiotensin-aldosterone system) inhibitor and a calcium channel blocker or non-thiazide diuretic. If target blood pressure values are not achieved within three months, a fixed triple combination of RAAS inhibitor, calcium channel blocker, and non-thiazide diuretic is indicated. This fixed triple combination leads to achieving target blood pressure values in more than 90% of hypertensive patients. The presented case report demonstrates the potential of fixed triple combination therapy.

Keywords: arterial hypertension, treatment, fixed combination, case report.

Published: February 20, 2025  Show citation