Med. praxi. 2023;20(2):94-96 | DOI: 10.36290/med.2023.014
Hepatitis E virus: a pathogen of rising significance
- Ústav veřejného zdraví LF Masarykovy univerzity, Brno
- Centra očkování a cestovní medicíny Avenier, a. s., Brno
Hepatitis E disease is caused by an RNA hepatitis E virus of the Hepeviridae family. The four genotypes pathogenic to humans account for more than 3 million symptomatic diseases worldwide each year. The disease is spread through the consumption of undercooked meat, contaminated water or food, or via person-to-person contact, depending on the virus genotype. Interhuman transmission is less common in our country. Hepatitis E infection is usually a mild disease. However, it may have severe extrahepatic manifestations and can be life-threatening in pregnant women and immunocompromised persons. There are thousands of deaths related to hepatitis E liver failure annually. So far, the only hepatitis E vaccine is authorized and used in China.
Keywords: hepatitis E, hepatitis E virus, genotypes, extrahepatic manifestations, vaccine.
Accepted: May 10, 2023; Published: May 10, 2023 Show citation
References
- Fousekis FS, Mitselos IV, Christodoulou DK. Extrahepatic manifestations of hepatitis E virus: An overview. Clin Mol Hepatol. 2020 Jan 1;26(1):16-23. doi: 10.3350/cmh.2019.0082.
Go to original source... 
Go to PubMed... - Odenwald MA, Paul S. Viral hepatitis: Past, present, and future. World J Gastroenterol. 2022 Apr 14;28(14):1405-1429. doi: 10.3748/wjg.v28.i14.1405. Go to original source... Go to PubMed...
- Pérez‑Gracia MT, García M, Suay B, et al. Current Knowledge on Hepatitis E. J Clin Transl Hepatol. 2015 Jun 28;3(2):117-126. PMCID: PMC4548356. doi: 10.14218/JCTH.2015.00009. Go to original source... Go to PubMed...
- World Health Organizations, Hepatitis E [Internet]. [cited 2022 Dec 22] Available from: https://www.who.int/news‑room/fact‑sheets/detail/hepatitis‑e.
- Raji YE, Toung OP, Taib NM, et al. Hepatitis E Virus: An emerging enigmatic and underestimated pathogen. Saudi J Biol Sci. 2022 Jan;29(1):499-512. doi: 10.1016/j.sjbs.2021. 09. 003. Go to original source...
- Damiris K, Aghaie Meybodi M, Niazi M, et al. Hepatitis E in immunocompromised individuals. World J Hepatol. 2022 Mar 27;14(3):482-494. doi: 10.4254/wjh.v14.i3.482. Go to original source... Go to PubMed...
- ClinicalTrials.gov, Effectiveness Trial to Evaluate Protection of Pregnant Women by Hepatitis E Vaccine in Bangladesh. NCT02759991 [Internet]. [cited 2022 Dec 22]. Available from: https://clinicaltrials.gov/ct2/show/NCT02759991.
- Výskyt vybraných hlášených infekcí v České republice, leden-prosinec 2022 [Internet]. [cited 2023 Jan 10]. Available from: https://szu.cz/uploads/documents/szu/infekce/2022/tabulka_leden_prosinec_2022.pdf.