Med. Pro Praxi 2007; 1: 17-20 [Interní Med. 2006; 8(11): 489-492]

Dnavá artritida a hyperurikemie

MUDr. Martin ®urek, doc. MUDr. Pavel Horák CSc
III. interní klinika FN a LF UP Olomouc

Dnavá artritida, nejčastějąí zánětlivé kloubní onemocnění muľů středního věku, bývá mnohdy nesprávně diagnostikována i léčena. Termín dna označuje heterogenní skupinu metabolických onemocnění, pro kterou je charakteristická tvorba depozit krystalů natriutrátů ve tkáních. V souhrnném článku je stručně zmíněna etiologie, patogeneze hyperurikemie a dny, diskutován je výskyt hyperurikemie v rámci metabolického syndromu X. Dna se klinicky projevuje jednak jako akutní dnavá artritida s klasickým klinickým obrazem, dále jako chronická tofózní dna, v oblasti ledvin jako akutní nebo chronická dnavá nefropatie. Základem diagnostiky dny je průkaz krystalů natrium urátu ve tkáních v kombinaci s typickým klinickým obrazem dny. V poslední části článku jsou shrnuty současné léčebné moľnosti dny a je diskutována rovněľ otázka léčby asymptomatické hyperurikemie.

Keywords: dna, hyperurikemie, metabolický syndrom X, akutní dnavá artritida, chronická tofozní dna, diagnostika dny, léčba dny, asymptomatická hyperurikemie

Published: January 1, 2007  Show citation

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®urek M, Horák P. Dnavá artritida a hyperurikemie. Med. praxi. 2007;4(1):17-20.
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    References

    1. Alper AB Jr, Chen W, Yau L, Srinivasan SR, Berenson GS, Hamm LL. Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension 2005; 45: 34-38. Go to original source... Go to PubMed...
    2. Becker MA, Schumacher HR Jr, Wortmann RL. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med 2005; 353 (23): 2450-2461. Go to original source... Go to PubMed...
    3. Bettencourt P, Ferreira A, Dias P, et al. Predictors of prognosisin patients with stable mild to moderate heart failure. J Card Fail 2000; 6: 306-313. Go to original source... Go to PubMed...
    4. Campion EW, Glynn RJ, deLabry LO. Asymptomatic hyperuricemia: the risks and consequences. Am J Med, 1987; 82: 421-426. Go to original source... Go to PubMed...
    5. Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 1999; 131: 7-13. Go to original source... Go to PubMed...
    6. Eastmond CJ, Garton M, Robins S, Riddoch S. The effects of alcoholic beverages on urate metabolism in gout sufferers. Br J Rheumatol 1995; 34: 756-759. Go to original source... Go to PubMed...
    7. Fernandez C, Moguera R, Gonzalez JA, et al. Treatment of acute attacks of gout with a small dose of intraarticular triameenalone acetonide. J Rheumatol 1999; 26: 2285-2286. Go to PubMed...
    8. Ganson NJ, Kelly SJ, Scarlett E. Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene) glycol (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase. Arthritis Res Ther 2005; 8 (1): R12 [Epub ahead of print]. Go to original source... Go to PubMed...
    9. Ghei M, Mihailescu M, Levinson J et al. Pathogenisis of hyperuricemia -recent advances. Curr Rheumatol Rep 2002; 4: 270-274. Go to original source... Go to PubMed...
    10. Hartus, E, Budd, R, Firestein, G et al. Kelley's Textbook of Rheumatology. 7. vydání. 2004. Saunders. 1402-1425.
    11. Hochberg, MC, Silman, AJ, Smolen, JS. Rheumatology. 3. vydání. Mosby 2003. 1920-1921.
    12. Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med 2004; 350: 1093-1103. Go to original source... Go to PubMed...
    13. Iacobuzio-Donahue CA, Lee EL, Abraham SC, et al. Colchicine toxicity. Distinct morphologic findings in gastrointestinal biopsies. Am J Surg Path 2001; 25: 1067-1073. Go to original source... Go to PubMed...
    14. Johnson RJ, Kang DH, Feig D, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 2003; 41: 1183-1190. Go to original source... Go to PubMed...
    15. Mazzali M, Hughes J, Kim YG, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001; 38: 1101-1106. Go to original source... Go to PubMed...
    16. Mikuls TR, Farrar JT, Bilker WB, et al. The treatment of asymptomatic hyperuricemia: results from the population-based general practice research database (GPRD). Arthritis Rheum 2003; 48 (suppl 9): S612.
    17. Pavelka K. Dna (arthritis urica). In: Pavelka K, Rovenský J a kol. Klinická revmatologie. Praha: Galen 2003. 952 s.
    18. Pavelka K. Terapie dny. In: Pavelka K a kol. Farmakoterapie revmatických onemocnění. Praha: Grada 2005; 349 - 350.
    19. Scott JT, Higgens CS. Diuretic induced gout: a multifactorial condition. Ann Rheum Dis 1992; 51: 259-261. Go to original source... Go to PubMed...
    20. Schlesinger N, Baker DG, Schumacher HR Jr. How well have diagnostic tests and therapies for gout been evaluated? Curr Opin Rheumatol 1999; 11: 441-445. Go to original source... Go to PubMed...
    21. Wallace SL, Robinson H, Masi AT. Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum. 1977; 20: 895-900. Go to original source... Go to PubMed...
    22. Zhang W, Doherty M, Pascal E et. all. EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the standing committee for international clinical studies including therapeutics (ESCISIT) Ann Rheum Dis 2006; 65: 1301-1311. Go to original source... Go to PubMed...

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