Med. praxi. 2013;10(3):108-110

Proton pump inhibitors

prof.MUDr.Milan Lukáš, CSc.

Klinické a výzkumné centrum pro střevní záněty 1. LF UK a ISCARE, a. s., Praha

Ústav biochemie a laboratorní diagnostiky 1. LF UK a VFN v Praze

Proton pump inhibitors (PPIs) introduction into clinical practice meant the significant advance in therapy of acido-peptic disorders. PPIs

are applicated to fasting patients on the morning in one daily dose usually. The treatment with other secretolytic drugs, which increase the

intragastric pH level simultaneously with PPIs are unfitting. PPIs are the most important drugs for the therapy of gastro-esophageal reflux

disease, peptic ulcer disease, Helicobacter pylori infection eradication and as well as there are the most powerful prophylactic therapy

against NSAIDs gastropathy. The long-term experience learning us that PPIs are a very safe therapy. Currently, an interaction between

PPIs and clopidogrel metabolisms which might induced a lower clopidogrel efficacy is under discussion.

Keywords: proton pump inhibitors, gastro-esophageal reflux disease, peptic ulcer, NSAIDs gastropathy

Published: March 15, 2013  Show citation