Med. praxi. 2014;11(2):78-81

Adverse effects and drug interactions of long-term proton pump inhibitor therapy

MUDr.Michal Prokeš, PharmDr.Josef Suchopár
INFOPHARM, a. s., Praha

Proton pump inhibitors (PPI) have an excelent safety profile. Long-term use is becoming increasingly common at variety of patients. This

paper is a brief review of current evidence and view on this important drug group, focusing on potential adverse effects of long-term PPI

use that have generated some concern: Vitamin B12 deficiency, iron deficiency, hypomagnesemia, bone fractures and enteric infections.

Clinical relevant drug-drug interactions of PPI are also mentioned.

Keywords: proton pump inhibitors, adverse drug reactions, drug-drug interactions

Published: March 15, 2014  Show citation

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Prokeš M, Suchopár J. Adverse effects and drug interactions of long-term proton pump inhibitor therapy. Med. praxi. 2014;11(2):78-81.
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