Med. praxi. 2014;11(6):270-274

Multiple sclerosis and pregnancy

MUDr.Olga Zapletalová

Centrum pro roztroušenou sklerózu, Neurologická klinika FN Ostrava, Lékařská fakulta OU, Ostrava

Multiple sclerosis is an autoimmune inflammatory and neurodegenerative disease affecting young women of childbearing age. Owing

to the knowledges and modern therapeutic approaches the illness can be really stable and women can carry out their biological

role and have children. Maternal immune system undergoes profound transformations at the very beginning of pregnancy. The major

changes are directed to protect the fetus from a detrimental immune response and the growing level of pregnancy hormones affects the

mother´s immune reactions. According to the results of the clinical trials and long-term clinical experience the pregnancy has positive

effect on the course of multiple sclerosis and the long term prognosis of the disease is not worsened due to pregnancy mainly in patients

with relapsing type. Multiple sclerosis has little or no direct effect on fertility, mode of delivery and on neonatal health.

Keywords: multiple sclerosis, pregnancy, delivery, disease modulating drugs, breastfeeding, pregnancy hormones, fertility

Published: December 1, 2014  Show citation