Med. praxi. 2016;13(5):268-274

Pharmacotherapy of cough in a nutshell

doc. PharmDr. Jan Juřica, Ph.D.
Farmakologický ústav LF MU v Brně, Biochemický ústav PřF MU v Brně

The article presents in tabular form the types of cough in terms of their symptomatology and the thus recommended pharmacotherapeutic group. Mucoactive agents can be classified into expectorants, mucolytics, mucokinetics, and mucoregulating drugs according to the effect on the composition and amount of sputum produced. Antitussives are divided into centrally and peripherally acting ones. The article presents the crucial pharmacological properties of each substance and/or extracts of medicinal plants. In conclusion, the basic pharmacotherapeutic approaches in treating dry and productive cough are summarized. The combination of antitussives and mucoactive agents are not rational and cannot be recommended.

Keywords: cough, antitussives, mucoregulating drugs, pharmacotherapy

Published: December 1, 2016  Show citation

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Juřica J. Pharmacotherapy of cough in a nutshell. Med. praxi. 2016;13(5):268-274.
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References

  1. Čáp P, Vondra V. Akutní a chronický kašel, Mladá fronta 2012: 159.
  2. Rubin B. Mucolytics, expectorants, and mucokinetic medications. Respiratory Care. 2007; 52(7): 859-865.
  3. Dynamed. 2016 Feb 18 ed: EBSCO; 2016.
  4. Lexicomp [online]. [cit. 2016-08-12]. Dostupný z: http://online.lexi.com/action/home.
  5. Thompson GA, Solomon G, Albrecht HH, Reitberg DP, Guenin E. Guaifenesin Pharmacokinetics Following Single-Dose Oral Administration in Children Aged 2 to 17 Years. J Clin Pharmacol. 2016; 56(7): 894-901. Go to original source... Go to PubMed...
  6. Zanasi A, Lanata L, Fontana G, Saibene F, Dicpinigaitis P, de Blasio F. Multidisciplinary Respiratory Medicine 2015; 10: 19. Go to original source... Go to PubMed...
  7. Juřica J. Farmakologické možnosti v léčbě kašle. Vox pediatriae, Praha: Medix 2014; 14(8): 19-23.
  8. Procházková M, Doležal T. Erdosteinum. Remedia 2004; 14(4): 297-304.
  9. AISLP-2016.3
  10. Balsamo R, Lanata L, Egan CG. Mucoactive drugs. Eur Respir Rev 2010; 19: 116, 127-133. Go to original source... Go to PubMed...
  11. Aliyali M, Poorhasan Amiri A, Sharifpoor A, Zalli F. Effects of N-acetylcysteine on asthma exacerbation. Iran J Allergy Asthma Immunol. 2010; 9(2): 103-109.




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