Med. praxi. 2017;14(3):115-122 [Prakt. lékáren. 2017; 13(2): 52-59]

Pharmacotherapy of irritable bowel syndrome

doc. PharmDr. Jan Juřica, Ph.D.^{1, 2}, MUDr. Radek Kroupa, Ph.D.³

1Farmakologický ústav LF MU, Brno

2Ústavní lékárna, Masarykův onkologický ústav, Brno

3Interní gastroenterologická klinika LF MU a FN Brno

Irritable bowel syndrome is one of the most frequent functional diseases of gastrointestinal tract. Among typical symptoms

there are GIT dyscomfort, abdominal pain, bloating, and change in stool consistency and/or stool frequency. Pharmacotherapy

is supplementary to dietary and regime approaches and is truly symptomatic, but it often brings patients significant relief from

symptoms. This article is pharmacological review of groups of drugs used in the treatment of irritable bowel syndrome. It introduces

mechanisms of action, particularities of pharmacokinetics of spasmolytics, laxatives, antidiarhoics, prokinetics, antibiotics

and psychotropic drugs in the treatment of irritable bowel syndrome and their position in the current range of medicines, based

on EBM and current guidelines.

Keywords: irritable bowel, pharmacotherapy, spasmolytics, laxatives, antidiarhoics, antidepressants

Published: July 1, 2017  Show citation