Med. praxi. 2017;14(4):193-195 | DOI: 10.36290/med.2017.056

Beta-lactam allergy today

MUDr. Lenka Sedláčková
Oddělení klinické biochemie, hematologie a imunologie, Centrum alergologie a klinické imunologie,
Nemocnice Na Homolce, Praha

Allergy to penicillin and other beta-lactams is the most frequently reported drug allergy. It is usually not questioned due to itsknown risk of severe and even fatal anaphylaxis. However, the diagnosis is often based on various symptoms in temporal connectionwith antibiotic use only, and is not checked any more. A complete allergy workup including a provocation test confirmsa true allergy only in a small number of patients. It can rid a patient of a false diagnosis and of a needless limitation of therapeuticpossibilities. Its wider application in practice is very desirable.

Keywords: penicillin, beta-lactam antibiotics, allergy, hypersensitivity

Received: June 12, 2017; Accepted: July 4, 2017; Published: November 1, 2017  Show citation

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Sedláčková L. Beta-lactam allergy today. Med. praxi. 2017;14(4):193-195. doi: 10.36290/med.2017.056.
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    References

    1. Baldo BA, Pham NH. Drug Allergy. Clinical aspects, diagnosis, mechanisms and structure-activity relationships. New York: Springer 2013: 447. Go to original source...
    2. Romano A, Caubet JS. Antibiotic Allergies in Children and Adults: From Clinical Symptoms to Skin Testing Diagnosis. J Allergy Clin Immunol Pract 2014; 2: 3-12. Go to original source... Go to PubMed...
    3. Romano A, Gaeta F, Vallutti RL, et al. IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity and tolerability of penicillins, monobactams, and carbapenems. J Allergy Clin Immunol 2010; 126: 994-999. Go to original source... Go to PubMed...
    4. Torres MJ, Montanez MI, Ariza A, et al. The role of IgE recognition in allergic reactions to amoxicillin and clavulanic acid. Clinical & Experimental Allergy 2016; 46: 264-274. Go to original source... Go to PubMed...
    5. Romano A, Gaeta F, Vallutti RL, et al. IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity and tolerability of alternative cephalosporins. J Allergy Clin Immunol 2015; 136: 685-691. Go to original source... Go to PubMed...

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