Med. praxi. 2019;16(1):48-52 | DOI: 10.36290/med.2019.007

Prostate cancer – what should we know about diagnostics

MUDr. Milan Král, Ph.D., MUDr. Šárka Kudláčková
Urologická klinika LF UP a FN Olomouc

During the last few decades we can see increasing incidence of prostate cancer. This is caused partially due to increased activity of medical stuff and partially due to higher information level of patients about potential risk of harbouring prostate cancer. Contrary to other oncological diagnosis (breast cancer, colorectal cancer), in prostate cancer the reason for screening programmes is widely discussed. Many multicentric projects assessed screening influence on prostate cancer mortality reduction. Conclusions both European and U.S. studies uniformly show that despite increased detection of prostate cancer, neither the cancer specific mortality nor overall survival improved. Based on these conclusions it is not recommended to perform wide but so called oportunistic screening. It means to examine men in risk age with regard to race and positive family history for prostate cancer with life expectancy at least 10–15 years. Aim of screening programmes is to increase detection of intermediate and high risk prostate cancers because especially these men profit the most from early detection and starting of active treatment, i.e. radical prostatectomy or radiotherapy.

Keywords: prostate cancer, diagnostics, screening

Published: February 25, 2019  Show citation

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Král M, Kudláčková Š. Prostate cancer – what should we know about diagnostics. Med. praxi. 2019;16(1):48-52. doi: 10.36290/med.2019.007.
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References

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018 Jan; 68(1): 7-30. Go to original source...
  2. Global Burden of Disease Cancer Collaboration, Fitzmaurice C. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2017 Apr 1; 3(4): 524-548.
  3. Webový portál www.svod.cz
  4. Sakr WA, Grignon DJ, Haas GP, Heilbrun LK, Pontes JE, Crissman JD. Age and racial distribution of prostatic intraepithelial neoplasia. Eur Urol. 1996; 30(2): 138-144. Go to original source... Go to PubMed...
  5. Bell KJ, Del Mar C, Wright G, et al. Prevalence of incidental prostate cancer: A systematic review of autopsy studies. Int J Cancer. 2015 Oct 1; 137(7): 1749-1757. Go to original source...
  6. Schröder FH, Hugosson J, Roobol MJ, et al. ERSPC Investigators. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 2009; 360(13): 1320. Go to original source...
  7. Roobol MJ, Kerkhof M, Schröder FH, et al. Prostate cancer mortality reduction by prostate-specific antigen-based screening adjusted for nonattendance and contamination in the European Randomised Study of Screening for Prostate Cancer (ERSPC). Eur Urol. 2009; 56(4): 584. Go to original source... Go to PubMed...
  8. http://uroweb.org/guideline/prostate-cancer/
  9. Pinsky PF, Prorok PC, Yu K, et al. Extended mortality results for prostate cancer screening in the PLCO trial with median follow-up of 15 years. Cancer. 2017; 123(4): 592. Go to original source... Go to PubMed...
  10. Ilic D, Neuberger MM, Djulbegovic M, Dahm P. Screening for prostate cancer. Cochrane Database Syst Rev. 2013. Go to original source...
  11. Fenton JJ, Weyrich MS, Durbin S, Liu Y, Bang H, Melnikow J. Prostate-Specific Antigen-Based Screening for Prostate Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force [on-line].
  12. Etzioni RD, Howlader N, Shaw PA, et al. Long-term effects of finasteride on prostate specific antigen levels: results from the prostate cancer prevention trial. J Urol. 2005; 174(3): 877. Go to original source... Go to PubMed...
  13. Thompson IM, Pauler DK, Goodman PJ, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level<or =4.0 ng per milliliter. N Engl J Med. 2004; 350(22): 2239. Go to original source...
  14. DeAntoni EP. Age-specific reference ranges for PSA in the detection of prostate cancer. Oncology (Williston Park). 1997 Apr; 11(4): 475-482, 485; discussion 485-486, 489. Go to PubMed...
  15. Belej K, Kaplan O, Köhler O, Kočárek J. Molekulární genetika a prostate cancer gene 3 (PCA3) v diagnostice karcinomu prostaty. Urolog. pro Praxi, 2010; 11(2): 82-85.
  16. Brierley JD, et al. TNM classification of malignant tumors. UICC International Union Against Cancer. 8th edn. 2017.
  17. Eichler K, Hempel S, Wilby J, et al. Diagnostic value of systematic biopsy methods in the investigation of prostate cancer: a systematic review. J Urol. 2006 May; 175(5): 1605-1612. Review. Go to original source... Go to PubMed...
  18. Alberts AR, Schoots IG, Bokhorst LP, van Leenders GJ, Bangma CH, Roobol MJ. Risk-based Patient Selection for Magnetic Resonance Imaging-targeted Prostate Biopsy after Negative Transrectal Ultrasound-guided Random Biopsy Avoids Unnecessary Magnetic Resonance Imaging Scans. Eur Urol. 2016 Jun; 69(6): 1129-1134. Go to original source... Go to PubMed...
  19. Valerio M, Donaldson I, Emberton M, et al. Detection of Clinically Significant Prostate Cancer Using Magnetic Resonance Imaging-Ultrasound Fusion Targeted Biopsy: A Systematic Review. Eur Urol. 2015 Jul; 68(1): 8-19. Go to original source... Go to PubMed...
  20. Kudláčková Š, Král M, Študent V, Koranda P. 18-F cholin PET/CT v primodiagnostice karcinomu prostaty. Ces Urol 2016; 20(1): 57-64.




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