Med. praxi. 2020;17(2):125-128 | DOI: 10.36290/med.2020.025
Risks of anti tumour therapy in daily practice
- 1 Masarykův onkologický ústav Brno
- 2 Farmakologický ústav, LF MU Brno
- 3 Ústav humánní farmakologie a toxikologie, FaF VFU Brno
- 4 Ústav technologie léků, FaF VFU Brno
The main risks of anti-tumour therapy that general practitioners encounter on daily basis include drug interactions and the management of side effects. Drug interactions are more frequent in the treatment of polymorbid patients. The patients treated for cancer are in greater risk because their therapy is often based on a combination of cytostatics, furthermore, they receive a whole array of supportive drugs. The treatment of cancer is accompanied by numerous side effects. The less significant ones can be managed in cooperation with general practitioners, thus improving the comfort and the compliance of the patient.
Keywords: drug interactions, side effects of cytostatics, cancer treatment.
Published: June 1, 2020 Show citation
References
- Riechelmann RP, Del Giglio A. Drug interactions in oncology: how common are they? Ann Oncol. 2009; 20: 1907-1912.
Go to original source... 
Go to PubMed... - Reimche L, Forster AJ, van Walraven C. Incidence and contributors to potential drug-drug interactions in hospitalized patients. J Clin Pharmacol 2011; 51(7): 1043-1050. Go to original source... Go to PubMed...
- Anzenbacher P, Anzenbacherová E. Cytochromes P450 and metabolism of xenobiotics. Cell Mol Life Sci 2001; 58(5-6): 737-747. Go to original source... Go to PubMed...
- Ritter J, Flower R, Henderson G, Rang H. ds. Rang & Dale's Pharmacology, 8E, vol. 8. Edinburgh; New York Elsevier/Churchill Livingstone; 2018.
- FDA. Drug Development and Drug Interactions: Table of substrates, inhibitors and inducers; 2020.
- Hansten PD. The underrated risks of tamoxifen drug interactions. Eur J Drug metab Pharmacokinet 2018; Oct; 43(5): 495-508. doi: 10.1007/s13318-018-0475-9. Go to original source... Go to PubMed...
- Alissa EM. Medicinal herbs and therapeutic drugs interactions. Ther Drug Monit. 2014 Aug; 36(4): 413-422. doi: 10.1097/FTD.0000000000000035. Go to original source... Go to PubMed...
- Kozáková Š, Ondra V, Halámková J. Zdraví ohrožující interakce fytofarmak a onkologické léčby. Onkologická revue 2019; 6.
- Hwang SW, Han HS, Lim KY, Han JY. Drug interaction between complementary herbal medicines and gefitinib. J Thorac Oncol. 2008 Aug; 3(8): 942-943. doi: 10.1097/JTO.0b013e3181803f1e. Go to original source... Go to PubMed...