Med. praxi. 2021;18(2):123-127 | DOI: 10.36290/med.2021.020

Venoactive drug therapy in surgical or endovenous treatment for varicose veins

MUDr. Robert Vlachovský, Ph.D.

II. chirurgická klinika, Centrum cévních onemocnění, FN u sv. Anny v Brně a Lékařská fakulta Masarykovy univerzity, Brno

Lower limb varicose veins can be treated with endovenous ablation procedures or with minimally invasive open techniques. We investigated whether venoactive drugs used to treat chronic venous disease (CVD), provide benefits to patients undergoing or recovering from a varicose vein procedure. We conducted a systematic review of the literature to identify clinical trials investigating venoactive drugs therapy before, during, or after a surgical, endovenous, or sclerotherapy procedure for varicose veins. We identified five clinical trials investigating the effects of venoactive drugs on recovery after interventions. All studies reported the use of micronized purified flavonoid fraction (MPFF), in one study, sulodexide was also used. Three studies reported significantly less post-procedural pain with MPFF treatment, two studies reported significant reductions in post-procedural bleeding with MPFF treatment. Three studies reported greater symptomatic improvement with MPFF treatment. Venoactive drugs therapy may help reduce post-procedural pain, hemorrhage, and CVD specific symptoms. New randomized studies are needed to clearly demonstrate the benefits and advantages mentioned above.

Keywords: varicose veins, chronic venous disease, varicose veins surgery, endovenous procedures, sclerotherapy, venoactive drugs.

Published: April 30, 2021  Show citation