Med. praxi. 2021;18(2):140-142

A new trend in initiating the treatment of hypertension

MUDr. Barbora Nussbaumerová, Ph.D.
Centrum preventivní kardiologie, II. interní klinika LF a FN v Plzni

A case report of a hypertensive man with mild hypertension and middle cardiovascular risk is presented. The pharmacotherapy of hypertension was iniciated with a fixed combination of an angiotensin enzyme inhibitor and a calcium channel blocker. This fixed combination was well tolerated. The blood pressure was decreased and the cardiovascular prognosis was improved.

Keywords: arterial hypertension, guidelines, fixed combination, cardiovascular risk.

Published: April 30, 2021  Show citation

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Nussbaumerová B. A new trend in initiating the treatment of hypertension. Med. praxi. 2021;18(2):140-142.
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    References

    1. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J 2018; 39(33): 3021-3104. Go to original source... Go to PubMed...
    2. Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS). European Heart Journal 2020; 41(1): 111-188. https://doi.org/10.1093/eurheartj/ehz455. Go to original source... Go to PubMed...
    3. Widimsky J, Filipovský J, Ceral J, et al. Doporučení pro diagnostiku a léčbu arteriální hypertenze ČSH 2017. Hypertenze Kardiovaskulární Prevence. 2018; Suppl. 19.
    4. The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2015; 373: 2103-2116. doi: 10.1056/NEJMoa1511939. Go to original source... Go to PubMed...
    5. SPC Prestance 5/5 mg, www.sukl.cz.
    6. Simons LA, Chung E, Ortiz M. Long‑term persistence with single‑pill, fixed‑dose combination therapy versus two pills of amlodipine and perindopril for hypertension: Australian experience. Current medical research and opinion 2017; 33(10): 1783-1787. doi: 10.1080/03007995.2017.1367275. PubMed PMID: 28805468; eng. Go to original source... Go to PubMed...
    7. Verma AA, Khuu W, Tadrous M, Gomes T, Mamdani MM. Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: A population-based retrospective cohort study. PLoS Med. 2018; 15(6): e1002584. Published 2018 Jun 11. doi: 10.1371/journal.pmed.1002584. Go to original source... Go to PubMed...
    8. Rea F, Corrao G, Merlino L, Mancia G. Early cardiovascular protection by initial two-drug fixed-dose combination treatment vs. monotherapy in hypertension. Eur Heart J. 2018; 39(40): 3654-3661. doi: 10.1093/eurheartj/ehy420. Go to original source... Go to PubMed...
    9. Cifkova R, Bruthans J, Wohlfahrt P, et al. 30-year trends in blood pressure, prevalence, awareness, treatment and control of hypertension in the Czech Republic. the Czech MONICA and Czech post-MONICA studies. 2019; 37: e47. Go to original source...
    10. Bertrand ME, Ferrari R, Remme WJ, et al. Clinical synergy of perindopril and calcium‑channel blocker in the prevention of cardiac events and mortality in patients with coronary artery disease. Post hoc analysis of the EUROPA study. Am Heart J. 2010; 159(5): 795-802. doi: 10.1016/j.ahj.2009. 12. 042. PubMed PMID: 20435188; eng. Go to original source... Go to PubMed...
    11. Dahlof B, Sever PS, Poulter NR, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipinu adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo‑Scandinavian Cardiac Outcomes Trial‑Blood Pressure Lowering Arm (ASCOT‑BPLA): a multicentre randomised controlled trial. Lancet 2005; 366(9489): 895-906. doi: S0140-6736(05)67185-1 (pii); 10.1016/S0140-6736(05)67185-1 (doi). Go to original source... Go to PubMed...
    12. ADVANCE Collaborative Group. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. The Lancet 2007; 370(9590): 829-840. doi: 10.1016/S0140-6736(07)61303-8. Go to original source... Go to PubMed...
    13. Hatalová K, Hatala R, et al. Optimization of blood pressure treatment with fixed-combination perindopril/amlodipine in patients with arterial hypertension. Clin Drug Investig 2012; 32(9): 603-612. Go to original source...

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