Med. praxi. 2024;21(5):293-300

Current trends in the use of bacterial lysates

MUDr. Zuzana Humlová, Ph.D.
Ústav imunologie a mikrobiologie 1. LF UK a VFN, Praha

Bacterial lysates stimulate the general immunity of the body in a non-specific way. They act on non-specific defense mechanisms, leading to an increase IgA in mucous membranes, phagocytic activity and interferon gamma production. They can also stimulate the production of specific antibodies against the bacterial antigens that make up the preparation. In many clinical trials, oral bacterial lysates have been shown to decrease the risk of recurrent respiratory infections in children and adults and reduce the need for antibiotics.

Keywords: bacterial lysates, non­‑specific immunity, specific immunity.

Published: December 2, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Humlová Z. Current trends in the use of bacterial lysates. Med. praxi. 2024;21(5):293-300.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Purchase PDF

    References

    1. Parola C, Salogni L, Vaira X, et al. Selective activation of human dendritic cells by OM-85 through a NF­‑kB and MAPK dependent pathway. PLoS One. 2013 Dec 30;8(12):e82867. Go to original source... Go to PubMed...
    2. Cazzola M, Anapurapu S, Page CP. Polyvalent mechanical bacterial lysate for the prevention of recurrent respiratory infections: a meta­‑analysis. Pulm Pharmacol Ther. 2012 Feb 25;(1):62-8. Go to original source... Go to PubMed...
    3. Marengo R, Ortega Martell JA, Esposito S. Paediatric Recurrent Ear, Nose and Throat Infections and Complications: Can We Do More? Infect Dis Ther. 2020 Jun;9(2):275-290. Go to original source... Go to PubMed...
    4. Greenberg D, Hoffman S, Leibovitz E, et al. Acute otitis media in children: association with day care centers--antibacterial resistance, treatment, and prevention. Paediatr Drugs. 2008;10(2):75-83. Go to original source... Go to PubMed...
    5. Stanek J, Príkazský V, Rosina J, et al. Preventive administration of GS Imunostim as a protection against acute respiratory infections. Cent Eur J Public Health. 2006 Sep;14(3):130-2. Go to original source... Go to PubMed...
    6. Bystroň J. Novinky v imunomodulační léčbě bakteriálními lyzáty u alergie a astmatu. Interní Med, 2019; 21(4):217-222. Go to original source...
    7. Bystroň J, Petrů V, Krčmová I. et al.: Účinnost a bezpečnost perorálního bakteriálního imunomodulátoru OLIMUNOVAC u pacientů s častými infekcemi dýchacích cest.(observační multicentrická studie). Alergie. 2011;13(1):58-65.
    8. Koukalová D, Kod'ousek R, Hájek V, Kolár M. Experimental nonspecific immunostimulation by the Propionibacterium acnes vaccine. Acta Univ Palacki Olomuc Fac Med. 1992;133:19-23. PMID: 1344592.
    9. Flores­‑Mireles AL, Walker JN, Caparon M, et al. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015 May;13(5):269-84. Go to original source... Go to PubMed...
    10. Ahumada­‑Cota RE, Hernandez­‑Chiñas U, Milián­‑Suazo F, et al. Effect and Analysis of Bacterial Lysates for the Treatment of Recurrent Urinary Tract Infections in Adults. Pathogens. 2020 Feb 6;9(2):102. Go to original source... Go to PubMed...
    11. Bystroň J. Imunomodulace u recidivujících infekcí močových cest. Urologie pro praxi. 2022;23(3),123-130. Go to original source...
    12. Melis GB, Piras B, Marotto MF, et al. The stimulation of the vaginal immune system with short­‑term administration of a vaginal gel containing fraction of Propionibacterium acnes, hyaluronic acid and polycarbophil is efficacious in vaginal infections dependent on disorders in the vaginal ecosystem. Gynecol Endocrinol. 2018 Oct;34(10):880-883. Go to original source... Go to PubMed...
    13. Unzeitig V, Stará A, Dvořák J, et al. Využití kvasinkového lyofilizátu CANDIVAC cps. u žen s rekurentní vulvovaginální kandidózou: výsledky klinické studie. Praktická gynekologie. 2012;16(2-4):71-4.
    14. Lau S. Oral application of bacterial lysate in infancy diminishes the prevalence of atopic dermatitis in children at risk for atopy. Benef Microbes. 2014 Jun 1;5(2):147-9. Go to original source... Go to PubMed...
    15. Del­‑Rio­‑Navarro BE, Espinosa RF, Flenady V, et al. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev. 2006;(4):629-717. Go to original source... Go to PubMed...
    16. Schaad UB: OM-85 BV, an immunostimulant in pediatric recurrent respiratory tract infections: a systematic review. World J. Pediatr. 2010;6(1):5-12. Go to original source... Go to PubMed...
    17. Olivieri D, Fiocchi A, Pregliasco F, et al. Safety and tolerability of ribosome­‑component immune modulator in adults and children. Allergy Asthma Proc. 2009; 30 (Suppl. 1):S33-S36. Go to original source... Go to PubMed...

    Return to the content


    Medicine for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.