Med. praxi. 2016;13(4):176-179 | DOI: 10.36290/med.2016.038

Dangerous drugs in patients with renal injury - when and how to reduce the doses

MUDr.Adéla Hrnčiříková¹, MUDr.Jan Vachek^1,2

¹ Interní oddělení s hemodialyzačním střediskem, Klatovská nemocnice a.s.

² Klinika nefrologie 1. LF UK a Všeobecné fakultní nemocnice v Praze

Chronic kidney disease (CKD) is defined by reduced glomerular filtration rate, albuminuria, and the cause of renal injury. Kidney disease, particularly

in the elderly population, is frequent; however, due to its asymptomatic nature, it is often overlooked or undiagnosed. If decreased

renal function is not taken into account when pharmacotherapy is chosen, the patient can easily be harmed. Patients with chronic kidney

disease are at an increased risk of adverse effects of pharmacotherapy; in them, kidney disease leads to affecting the majority of pharmacokinetic

parameters and, at the same time, the comorbidities typically present require the administration of additional drugs, which increases

the risk of drug-drug interactions. In elderly patients, it is advisable to follow the list of recommended and unrecommended medications

in old age. In a number of drug groups, the selection and dose of the drug must be adjusted not later when reduction of renal function to

stage G3b occurs. The paper presents examples of drugs from drug groups most commonly used in the surgeries of general practitioners.

It includes mechanisms of potential patient harm due to inappropriate pharmacotherapy and instructions on how to reduce this risk.

Keywords: chronic kidney disease (CKD), drug dosage, glomerular filtration rate

Published: October 1, 2016  Show citation