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doc. MUDr. Bohumil Seifert, Ph.D.

Med. praxi. 2017;14(4):161  

Combination therapy of risk factors of atherosclerosis in clinical practise

MUDr. Lukáš Zlatohlávek, Ph.D., MUDr. Eva Tůmová, MUDr. Michaela Šnejdrlová, Ph.D.

Med. praxi. 2017;14(4):164-167 | DOI: 10.36290/med.2017.055  

Cardiovascular diseases are still the leading cause of morbidity and mortality in developed countries. Only by complex reviewincluding all risk factors of atherosclerosis are we able to optimally reduce the risk of the patient. Combining drug group enablesthe patient to achieve a certain target value, and obtain improve results due to increasingly strict and clear recommendations.With the increasing amount of pharmacological therapy, the patient adherence to physical therapy unfortunately decreases.Fixed combinations are the most perspective solution for patient adherence to a drug therapy. Nowadays, there are not onlyfixed combinations (especially)...

Thyroid glard disorders in pregnancy

MUDr. Nataša Kaňová

Med. praxi. 2017;14(4):169-172 | DOI: 10.36290/med.2017.031  

Physiological changes in pregnancy influence thyroid hormone levels which should be taken into consideration when assessingthe laboratory results of pregnant women. The most common disease of thyroid glands in pregnancy is autoimmune thyroiditis,which can cause hypothyroidism. Graves Basedow disease detrimentally affects the course of pregnancy and it´s essential tobe treated unlike transient hyperthyroidism, which disappears on its own without treatment. The diagnosis of the goiter andthyroid nodules during pregnancy has some specific difficulties and requires a particular attitude. Crucial to an optimal courseof pregnancy is the sufficient intake...

What are the benefits of the combination of perindopril and amlodipine in treating hypertension?

MUDr. Jan Pyszko, doc. MUDr. Jan Václavík, Ph.D., FESC

Med. praxi. 2017;14(4):173-176 | DOI: 10.36290/med.2017.032  

The treatment of arterial hypertension is not only aimed at maintaining blood pressure below target levels. Modern therapy shouldalso be well tolerated, have simple dosage in order to achieve good patient adherence, and, in particular, positively influencecardiovascular morbidity and mortality of patients. The treatment based on perindopril has the largest evidence base and, in thefixed combination with amlodipine, represents the drug of choice in many clinical settings.

Peptic ulcer disease

MUDr. Michal Konečný, Ph.D.

Med. praxi. 2017;14(4):177-179 | DOI: 10.36290/med.2017.033  

The incidence of peptic ulcers in areas of natural resistance to aggressive constituents of digestive juices is called gastroduodenalulcer disease. After the discovery of the main etiological factors, Helicobacter pylori infection and the overuse of nonsteroidalanti-inflammatory drugs, the introduction of advanced endoscopic diagnostic methods and proton pump inhibitors into clinicalpractice dramatically improved the prognosis of patients with gastroduodenal ulcer disease and significantly reduced the recurrencerate. The most serious complications include bleeding and perforation of the ulcer, serious adverse events of which themorbidity and mortality...

Sphincter dysfunction in patients with multiple sclerosis

MUDr. Miroslava Ryšánková

Med. praxi. 2017;14(4):50-55  

Multiple sclerosis (MS) is a disease mainly affecting younger individuals aged 20 to 40 years. It is a chronic inflammatory diseaseof the central nervous system (CNS). The first symptoms of the disease most common sensory, otor or visual diffculties. Many patientsdevelop early urological problems, in particular sphincter dysfunction. Therefore, it is necessary for a urologist to considerMS in young patients with these complaint and, if this is lacking, to evaluate the patient neurologically.

Snoring – a life threatening condition?

MUDr. Milada Hobzová, Ph.D., MUDr. Richard Salzman, Ph.D.

Med. praxi. 2017;14(4):180-184 | DOI: 10.36290/med.2017.034  

Snoring is sometimes downplayed as a sound disturbing the sleep companion. However, it affects the snorer him/herself aswell. The snoring should not be ignored as it may indicate a presence of more serious illness, i.e. sleep apnea. Obstructive sleepapnea has a negative impact on the patient’s health and negatively affects patient’s quality of life. It is associated with fatiqueand sleepiness often leading to momentary drowsiness. Another symptom is a presence of microsleep episodes during daytimeposing an increased likelihood of car accidents. Furthermore, obstructive sleep apnea increases risks of metabolic and cardiovasculardiseases....

Seborrhoeic dermatitis, differential diagnosis and treatment in the practice

MUDr. Naděžda Vojáčková

Med. praxi. 2017;14(4):185-188  

Seborrhoeic dermatitis is among common skin conditions with a chronically recurrent course, most frequently occurring in theface and hairy part of the head. The differential diagnosis must include perioral dermatitis, rosacea, atopic eczema, psoriasis,microbial eczema, mycoses, and other less frequent entities. The treatment is usually local using external agents with antifungal,antimicrobial, and anti-inflammatory effects.

Beta-lactam allergy today

MUDr. Lenka Sedláčková

Med. praxi. 2017;14(4):193-195 | DOI: 10.36290/med.2017.056  

Allergy to penicillin and other beta-lactams is the most frequently reported drug allergy. It is usually not questioned due to itsknown risk of severe and even fatal anaphylaxis. However, the diagnosis is often based on various symptoms in temporal connectionwith antibiotic use only, and is not checked any more. A complete allergy workup including a provocation test confirmsa true allergy only in a small number of patients. It can rid a patient of a false diagnosis and of a needless limitation of therapeuticpossibilities. Its wider application in practice is very desirable.

Adverse effects of metoclopramide (Degan) – from a patient’s perspective

MUDr. Ľubica Cibičková, Ph.D., MUDr. Miroslava Jelínková

Med. praxi. 2017;14(4):89-206  

Metoclopramide is a widely used and potent drug. It is indicated in many cases, but it should always be administered with respectto its potential side effects. This case report describes the development of fatigue, drowsiness and akathisia with gradualprogress into Parkinson´s syndrome, anxiety and depression. The therapy of these severe side effects included amantadine andclonazepam followed later by antidepressants.

Tick-borne encephalitis – a disease with variable outcome

MUDr. Martina Pýchová, prof. MUDr. Petr Husa, CSc., MUDr. Lenka Fašaneková, MUDr. Radana Pařízková, MUDr. Michaela Freibergerová, MUDr. Martin Slezák

Med. praxi. 2017;14(4):199-202  

A tick is one of the most important vectors of infectious diseases worldwide. Tick-borne encephalitis (TBE) is one of them. TheCzech Republic belongs among countries with the highest occurrence of the disease. Clinical presentation and relevance arevariable – from asymptomatic or abortive forms to classical neurological manifestation such as meningitis, encephalitis, meningoencephalomyelitiseven death. Complications are more often seen in elderly people and consequences of the disease(post-encephalitic syndrome, palsies) can be permanent. Specific treatment still does not exist and vaccination is the only effectiveprotection against TBE.

Primary detection of arterial hypertension in a patient with a risk history

MUDr. Kateřina Študentová

Med. praxi. 2017;14(4):207-211 | DOI: 10.36290/med.2017.040  

The case report describes detection of essential arterial hypertension in a young patient. This patient’s cardiovascular risk is lowaccording to the SCORE chart. However, given his alarming family history and unhealthy lifestyle, he needs to be considered, inthe long-term perspective, a high-risk patient. The treatment of such a patient must be managed properly since the beginning. Itis necessary to choose an antihypertensive drug providing maximum cardiovascular protection at a dose that will control bloodpressure sufficiently. It is important to motivate the patient to change his lifestyle, particularly in terms of rational eating, sufficientregular...

Proteinuria

MUDr. Jan Vachek, PhDr., MUDr. Oskar Zakiyanov, Ph.D., prof. MUDr. Vladimír Tesař, DrSc.

Med. praxi. 2017;14(4):196-198  

Proteinuria is not only a cardinal sign of primary and secondary nephropathies, but also an independent pathogenic factor ofprogression of these diseases. Along with the serum creatinine level, red blood cell urine test, and renal ultrasound, qualitative andquantitative data on proteinuria belong to the basic nephrological evaluation. In routine practice, the dipstick test is used for thescreening of proteinuria; this, however, cannot detect microalbuminuria, Bence-Jones proteinuria (free light chains, for instance,in multiple myeloma), and signs of tubulointerstitial diseases. For a more precise evaluation of albuminuria and/or proteinuria,the urine...